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Cell survival is further enhanced by upregulation of GR by proinflammatory cytokines such as IL-8 in the presence of glucocorticoids during inflammation (218)

CRC Press, pp 6182 Clare DA, Rabinowitch HD, Fridovich I (1984) Superoxide dismutase and chilling injury in Chlorella ellipsoidea

Specifically, two mechanisms stand out: 1) a rapid G protein-dependent, ERK1/2 activation that results in ERK1/2 translocation into the nucleus and 2) a more sustained -arrestin-mediated endocytosis-dependent pathway that results in a pool of ERK1/2 that remains in the cytoplasm (Daaka et al., 1998)

Epigenetic regulators further contribute to this multilayered control through histone acetylation, methylation, and chromatin remodeling

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