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ATP depletion stimulates PKC-alpha activity and leads to translocation of the enzyme to the plasma membrane, thereby enhancing serine phosphorylation of membrane proteins, such as the Ca 2+ -permeable cation channel (Fig
Studies have shown that pancreatic cells in T2DM patients exhibit more abundant autophagic vacuoles and autophagosomes than cells in non-diabetic patients, and the expression of lysosomal genes is lower, indicating that T2DM leads to changes in the level of autophagy structure removal [103]

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