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Pivotal role of STAT3 in shaping glioblastoma immune microenvironment

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Some reports ( Reference Betz, Ren and Ennis 53 Reference Seekamp, Hultquist and Till 56 ) have indicated that riboflavin can alleviate oxidative injuries in these situations, probably through its ability to scavenge free radicals

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Therefore, therapeutic approaches may need to be more nuanced, perhaps targeting specific drivers of pathological senescence, modulating the harmful components of the SASP (senomorphics), or selectively targeting only the chronically persistent senescent cells