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Figure 1 2.1 Regulation of the GPX 4 regulatory pathway Cells are affected by multiple signal-regulating channels, such as apoptosis, necrotic and ferrotic channels
Treatment of SOD1 G93A mice found that this compound improved the neurological phenotype of the animals, as assessed by motor performance tests, decreased spinal cord pathology, delayed the time to symptom onset, and improved survival in a dose-dependent manner (Hilton et al., 2017

10.1016/j.jconrel.2020.10.069 26 GuoS.NakagawaY.BarhoumiA.WangW.ZhanC.TongR.et al (2016)

2016;7:e0224215

Our data provide important new information concerning potential interactions between GSSG, protein glutathionylation, and TNF-induced hepatotoxicity, as well as its critical involvement in the pathogenesis of NAFLD
