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Plasma sphingolipids, lung function and COPD: the Cardiovascular Health Study
However, this theory is in dispute because through in vitro techniques using microfluidic chambers, Gornstein and Schwarz have recently found that the distal part of the axon is selectively sensitive to PCTX (Gornstein and Schwarz, 2017)

Because the body does not store significant amounts of most B vitamins, consistent intake and absorption are required to maintain adequate levels

doi: 10.1016/j.freeradbiomed.2015.04.029

There is also a potential higher risk of certain cancers associated with its use
