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Heavier individuals with more adipose tissue often benefit from doses at the higher end of the standard range (450-500mcg)

This peripheral inflammation is a known driver of neuroinflammation, which is implicated in mood disorders, cognitive decline, and neurodegenerative diseases

PMID 27886869

The events where D62 is correct include trauma with significant blood loss, post-surgical bleeding, ruptured aortic aneurysm, acute gastrointestinal hemorrhage from a bleeding ulcer or variceal bleed, and ectopic pregnancy rupture