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However, despite these promising advantages, clinical research is still limited, and FDA approval has not been granted

H3K27 trimethylation) Derepress oncogenic gene expression Silence tumor suppressor loci 4.2 Mechanistic Studies In oral squamous carcinoma-associated fibroblasts, NNMT overexpression reduces H3K27 methylation , enabling ETS2 transcription, which then increases VEGFA expression and promotes angiogenesis

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1996 May;53(5):441-8

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