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In particular, the aldehyde derivatives of LPO promote the production of pro-inflammatory cytokines and the apoptosis of keratinocytes and melanocytes, and they inhibit antioxidant enzymes

Singh Raghav KP, Xiao L, Lewis C, Zeller BE, Overman MJ, Huey RW, Dasari A, Chang K, Quinn K, YC Shen JP, Parseghian CM, Willis J, Ludford K, Van K Morris II, Wolff RA, Wang XS, Drusbosky L, Kopetz S

TRAP1 is a cellular substrate for the PINK1 kinase, and mutations in the TRAP1 gene in Drosophila models lead to significantly reduced dopamine levels and decreased complex I activity

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At Pennsula Valds in Argentina, for example, hundreds of southern right whales ( Eubalaena australis) died on their calving ground between 2003 and 2011