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Tian H, Xiong Y, Zhang Y, Leng Y, Tao J, Li L, et al

(A) H&E staining of the liver (400), (B) steatosis histology scores, (C) hepatic lipid concentration, (D) alanine transaminase (ALT) levels, (E) aspartate aminotransferase (AST) levels, (F) -oxidation-related protein expression in the liver, (G) hepatic malonyl coenzyme A (CoA) content, (H) hydroxymethylglutarylCoA reductase (HMGCR), sterol regulatory element-binding protein-2 (SREBP2), proprotein convertase subtilisin/kexin type 9 (PCSK9), and low-density lipoprotein receptor (LDLr) mRNA expression in the liver, (I) serum lipid profiles in C57BL/6J mice during 8 weeks of normal-fat diet (ND) or high-fat diet (HFD) feeding

One of the primary challenges in pulmonary administration is the presence of ciliated epithelial cells that transport mucus and alveolar fluids, with mucociliary clearance being a vital process responsible for the removal of debris and any unwanted particles inhaled