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Currently, the most commonly used antibodies are Empliciti (elotuzumab), Darzalex (daratumumab), and Sarclisa (isatuximab)

Older patients or those with multiple comorbidities may experience slower improvement

PMID: 224 UmemuraMHondaAYamashitaMChidaTNoritakeHYamamotoKet al

The mechanism cited most often in the preclinical literature is upregulation of vascular endothelial growth factor signaling (VEGFR2) alongside modulation of the nitric-oxide system