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Keap1-Nrf2 signaling pathway: mechanisms of regulation and role in protection of cells against toxicity caused by xenobiotics and electrophiles

Oncology 82(2):108-13, 2012

Experimental studies conducted on the use of NAC in NAFLD patients have demonstrated that NAC can block the accumulation of hepatic lipids and reduce the pro-inflammatory cytokines IL-6, IL-1, and TNF- and the upstream transcription factor NF-B [47], which plays a critical role in initiating the inflammatory cascade and immune response related to oxidative stress

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