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However, substituting the ethoxy with larger aliphatic ether groups was better tolerated both in terms of TRF1 TRFH binding and aqueous solubility ( 30 , 31 , 32 )

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Subcutaneous administration suffers from: Lower bioavailability Variable absorption Different pharmacokinetics Which means the systemic exposure of DSIP via subcutaneous administration is not equivalent to what is achieved with intravenous infusion

Maintenance of mitochondrial homeostasis is important for cellular function and survival

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