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5 , 6 It appears that acute treatment strategies (shortly after the induction of disc injury) as used and studied in most preclinical IVD degeneration models do not reflect the real life clinical chronic pain situation

The pathogenesis of DKD arises from multifaceted interactions among metabolic disturbances, inflammatory cascades, and fibrotic remodeling mediated by Transforming Growth Factor Beta (TGF-) signaling (4, 5)

The compounding pathway does not solve the problem either

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[DOI] [PubMed] [Google Scholar] 38.Masumoto K, Takeyasu A, Oizumi K, Kobayashi T
