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Description
J Biol Chem 290(47):2809728106
This estimate of 71% for the proportion of Cys catabolized by cysteinesulfinate-dependent pathways in intact rats is similar to the estimate of 63% for hepatocytes isolated from rats fed an adequate diet and incubated with 0.2 mM Cys in vitro
The animals were rated daily for Parkinsonian symptoms and dyskinesia using a PD clinical rating scale optimized for macaques 39,45,73 and a dyskinesia disability scale 74
persici , possibly together with reduced strain diversity (dominance of specific strains), appears to confer an adaptive phenotype in SL
The long-term safety data from the lifespan studies in CBA mice is particularly relevant
