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Is SOD1 loss of function involved in amyotrophic lateral sclerosis
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Consistent with this notion, others showed that A42-mediated inhibition of cytochrome- c oxidase was dependent on both Met35 residue being reduced (and thus able to undergo a 1-electron oxidation) and A42s ability to bind and reduce Cu 2+ to Cu + (117)
Lazarus, M
From lead to market: chemical approaches to transform peptides into therapeutics
