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Although functional data supporting a trans- inhibition model were obtained when constitutive activation of JAK2 was shown with a JAK2 construct where the pseudokinase and KDs were swapped and this construct showed significant cytokine-independent activation only in the presence of wild-type JAK2 (51)

Stacking Protocols Stacking with other GLP-1 agonists (tirzepatide, liraglutide) is described as redundant overlapping mechanisms increase side effects without proportional benefits

The authors also thank Vishnu Patel and Caitlin Travers for assistance with the systematic review and for careful reading of the manuscript

These mechanisms hold significant importance in diseases such as osteoporosis, atherosclerosis, and post-traumatic bone repair, and targeting these cells (e.g., inhibiting mast cells) may ameliorate the dysregulation of the bone-vascular axis (88, 89)