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The use of either GABAA or GABAB receptor agonists alone can partially reverse VPA-induced ASD behaviors, while the combination of clonazepam and baclofen can more effectively improve social deficits, enhance recognition memory, and reduce repetitive behaviors ( Baclofen treatment normalizes the abnormal auditory-induced gamma oscillations, working memory, and anxiety-related behaviors but does not improve the deficit in sociability ( Arbaclofen, the R-enantiomer of baclofen, has been shown to significantly reduce repetitive grooming behaviors in Fmr1 knockout mice following acute injection, and systemic treatment improved sensory filtering abilities in Cntnap2 knockout rats, suppressing excessive acoustic startle responses ( post hoc analyses suggested potential benefits in prespecified subgroups, including those with higher baseline anxiety or lower cognitive functioning, warranting further investigation in these subpopulations

Unlike synthetic Wnt agonists, which can create unwanted off-target stimulation, the tripeptide appears to nudge Wnt signaling within a biological operating range