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Intravenous steroids can cause patients to retain salt and fluid, leading to a gain of three to five pounds during a three- to five-day course of treatment

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Fusion arrest by polyubiquitination and proteasomal degradation of mitofusins (Mfn1 and Mfn2) by Parkin is required for mitophagy (Figure 4.4)

Animal studies have substantiated this by showing that mice deficient in ACC1 possess fewer IL-17A-producing CD4+ T cells and increased expression levels of Foxp3 in CD4+ T cells