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The structure of the E-domains has not been resolved, and their molecular functions are still unclear

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Because the fatty acid carrier molecule, acyl-CoA, cannot cross the mitochondrial cell membrane, a carnitine deficiency causes a reduction in the concentration of fatty acids in the mitochondria and, consequently, reduced energy production

Taken together, this is the first study to describe the hepatic metabolome after ischemic AKI in a murine model and demonstrates that there is significant liver-kidney crosstalk after AKI.