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54 , e140e145 (2015)

The carbonyl content was calculated from peak absorption (360 nm) using an absorption coefficient (e) of 22,000 M-1cm -1

This progressive deterioration of biological signaling is precisely what makes peptides an attractive therapeutic target

For example, in some embodiments, an antibody or an antigen-binding portion thereof identified ' using the methods of the invention can be modified, to thereby modify the binding affinity of the antibody or antigen-binding portion thereof to ALPP/ALPPL2