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Description
MSU crystals detect exogenous purine stimulation by activating purinergic receptors, which initiates the Raf/MEK/ERK signaling cascade

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Pathophysiol 11 (1), 119

They include NSAIDs, paracetamol, COX-2 inhibitors, and adjuvant agents

Immunological assays such as ELISA and immunofluorescence detect specific lesions like 8-oxo-2-deoxyguanosine (8-oxo-dG), a common oxidative stress marker (Gonzalez-Hunt et al., 2018
