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Description
The Be(2)-C cell line was selected due to its similar response profile as spheroids and delayed response to treatment compared to both MNA NB cell lines IMR-5/75 and IMR-32
According to NICE Clinical Knowledge Summaries, B12 supplementation for confirmed deficiency should follow established protocols, but routine monitoring of B12 levels after treatment initiation is not always necessary unless clinical response is inadequate
Research-Based Cycle Protocols Short-Term Assessment (4-8 Weeks): An initial 4-8 week cycle allows evaluation of individual response, tolerance assessment, and metabolic changes without extended commitment
Anecdotal reports suggest administering reduced dosages over cycles lasting 8-12 weeks
benefits are generally greatest when B12 or other nutrient status is genuinely low
