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The key reaction is the Fenton reaction, where ferrous iron (Fe 2+ ) reacts with hydrogen peroxide (H 2 O 2 ) to produce highly reactive and damaging hydroxyl radicals ( OH) [94]

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In each treatment group, peak HV was observed during treatment Year 1, and then gradually decreased each year

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Alternatively, GPX4 depletion initially triggers pyroptotsis and subsequently regulates inflammation and ferroptosis

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[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Yan S., Xu D., Wang P., Wang P., Liu C., Hua C., Jiang T., Zhang B., Li Z., Lu L., et al

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