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Some of the symptoms, especially early on, can be vague

We propose that chronic exposure to a particular suite of environmental and genetic factors elicits a trajectory of impaired mitochondrial biology that maximally impacts subsets of mitotypes abundant in the substantia nigra, striatum, and cerebral cortex, which eventually surfaces as the hallmark features of PD

doi: 10.1172/jci.insight.163030 105 XuDZhangSHuangCHuangCQinLLiXet al

doi: 10.1016/j.biomaterials.2013.05.043

The diminished levels of trait-dependent OXT observed in children with ASD is indicative of dysfunctional coupling between OXT and cortisol, which may potentially underlie the deficiency demonstrated by children with ASD in the protective mechanisms that counteract social stressors [87]