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When B12 levels become problematic: High-dose supplementation (particularly doses exceeding 1,000 micrograms daily) Frequent B12 injections without medical supervision Underlying conditions affecting B12 metabolism Concurrent use of multiple B12-containing supplements The NHS does not set an upper safe limit for vitamin B12 because harmful effects from excessive intake have not been definitively established

If not, the nurse advised me to use one needle to draw the cobalamin from the ampule, then use a fresh one to inject

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doi: 10.1177/1179546817694558 133 OkanoMNishitaniYSatoMIkekitaAKageyamaS