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Interactions with Benzodiazepines and Other CNS Depressants Inform patients and caregivers that potentially fatal additive effects may occur if acetaminophen and codeine phosphate tablets used with benzodiazepines or other CNS depressants, including alcohol, and not to use these drugs concomitantly unless supervised by a healthcare provider [see WARNINGS, PRECAUTIONS

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Special attention should be paid to standardizing extracts, determining optimal dosing, and investigating potential herb-drug interactions

doi: 10.1016/S0140-6736(14)61682-2

Kochanek, S