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Nucleic Acids Res 28:304305

Detoxification capacity drops, reactive oxygen species accumulate, inflammatory cascades escalate, mitochondrial ATP production becomes inefficient, and immune surveillance weakens

elegans experiments, to Alejandra Atorressi and Cora Pollack for help with FACS and microscopy experiments
187 High LPAR3 expression is correlated with improved regeneration, whereas LPAR4 is associated with worsened outcomes 187,188 Despite the reparative roles of LPAR2/3, elevated systemic LPA after MI exacerbates injury

1h), which would trigger p53-dependent apoptosis 13
