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The most frequently reported side effects in the SURMOUNT clinical trials included gastrointestinal symptoms such as nausea (25-29%), diarrhea (21-23%), vomiting (8-9%), constipation (17-20%), and abdominal pain (8-9%)

Strong interest in TB-500s effect on wound healing stems from a 2005 Phase I clinical trial, which found that the peptide plays a key role in dermal- and corneal-wound healing and could support healing in chronic cutaneous wounds

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