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Similar to rodent models, patients with anorexia also exhibit significant increases in BMAT along with impaired bone quality (3, 69, 70, 140, 154, 202, 458)
Furthermore, Oxford Academic publications [4] report that disruption of MC4 receptor function produces hyperphagia and obesity phenotypes, further reinforcing receptor-specific mechanisms involved in appetite regulation

2021 May 1;78(5):510-518

Effectiveness of "Moro" Blood Orange Citrus sinensis Osbeck (Rutaceae) Standardized Extract on Weight Loss in Overweight but Otherwise Healthy Men and Women-A Randomized Double-Blind Placebo-Controlled Study

The pharmacokinetic rationale is questionable given the 5-day half-life, but some users report better side effect tolerance with split dosing
