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Radioresistant HIF1 KO cancer cells are more sensitive to ser/gly synthesis inhibition by sertraline We recently demonstrated that by blocking the bi-directional conversion of serine to glycine through serine hydroxymethyltransferase (SHMT) inhibition, the repurposed compound sertraline could enhance irradiation responses, ultimately reducing NSCLC tumor growth [10]

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Interleukin 33-mediated inhibition of A-type K(+) channels induces sensory neuronal hyperexcitability and nociceptive behaviors in mice