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Description

-MSH released by the POMC neurons then signals to decrease energy intake by binding to melanocortin-4 receptor (MC4R) expressed by MC4R neurons to the paraventricular nucleus (PVN)

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By inhibiting cyclin D1 and activating p21 to arrest cell cycle progression, while simultaneously promoting pro-apoptotic Bax and suppressing anti-apoptotic Bcl-2, C/EBP establishes a multi-pronged tumor-suppressive mechanism [85]