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Outside the CNS, serotonin is produced in the ENS and released predominantly by enterochromaffin cells (estimated to be up to 90% of the body's serotonin production [169]) of the gut mucosa and immune cells, with influence not only on the ENS but also on the CNS via the GBA [283]

Metabolic reprogramming supplies biosynthetic precursors and energy to support tumor proliferation, activates oncogenic signaling, protects against oxidative stress and apoptosis, enhances adaptation to the tumor microenvironment, and promotes the development of drug resistance

doi: 10.3389/fpls.2016.01942

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10.1016/j.marpolbul.2004.11.012 Mar