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Description
As a transcription factor, ATF4 upregulates lysine transporters (e.g., SLC7A1) and catabolic enzymes (e.g., -aminoadipate semialdehyde synthase), enhancing lysine uptake and emergency catabolism
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increased expression of NEAT1 downregulates let-7a, removing the miRNA block on IGF-2 expression, and resulting in increased NSCLC cell proliferation, migration and invasion [25]
