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Dawson MA, Kouzarides T

Furthermore, post-hoc power analysis of this study indicated that 80% power would be achieved at 461 participants/group and 90% power at 617 participants/group using a 5% significance level with 2-tailed test

The authors noted that poor or intermediate metabolizers demonstrate reduced drug clearance, which can elevate systemic exposure and increase ADR risk, whereas rapid or ultrarapid metabolizers may experience subtherapeutic exposure and treatment failure

Al-Sadi, R., Ye, D., Dokladny, K

Springer Nature Hasanuzzaman M, Hossan MA, Da Silva JAT, Fujita M (2011) Plant response and tolerance to abiotic oxidative stress: antioxidant defense is a key factor