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J Adv Pharm Technol Res

Glucose-dependent insulinotropic polypeptide (GIP)

doi: 10.1016/j.cbi.2018.04.023 52 TianXRuQXiongQWenRChenY

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SEL is conjugated with PEG using a reactive oxygen species (ROS)-responsive linker, forming a PEG-SEL prodrug that self-assembles into micelles as a delivery vehicle for OSI, co-delivering OSI and SEL nanoparticles effectively overcoming OSI resistance in NSCLC [111].For ALK-positive NSCLC patients, although there is a good response to ALK tyrosine kinase inhibitor (TKI) therapy, drug resistance eventually develops
