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MSS CRC cells often exhibit elevated glycolytic and OXPHOS activity, leading to excessive consumption of glucose and oxygen within the tumor microenvironment (TME), thereby depriving effector immune cells such as CD8 T cells of essential metabolic resources [82]

Pyrosequencing was used to ascertain the 15-LOX-1 promoter's DNA methylation status

Nitric oxide (NO) is a naturally occurring molecule in the body that plays a pivotal role in cardiovascular and muscular health

Subsequently, we found that the predominant microbial phylum in the duodenum was Firmicutes , followed by Bacteroidota, Patescibacteria, Actinobacteriota , and Verrucomicrobiota (Figure 10D)