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However, the basic nephrotoxin in these herbal remedies has been identified as a diterpene glycoside atractyloside, which in animal studies has been found to affect renal cortical mitochondria and proximal tubular fragments

There was evidence that the secondary depletion of amino acids caused by blocked respiration might be the primary cause of ISR activation 154

Folate receptors are cellular membrane glycoproteins comprising three isoforms, namely FR, FR, and FR [23]

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Pretreatment with 20 M astaxanthin reduced MDA, protein carbonylation, and 8-oxo-2-deoxyguanosine levels, indicating antioxidant action