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Pharmacokinetic scaling across species rodent to larger animal to human extrapolation has not been rigorously published

[PUBMED Abstract] Hastings C, Gaynon PS, Nachman JB, et al.: Increased post-induction intensification improves outcome in children and adolescents with a markedly elevated white blood cell count (200 10(9) /l) with T cell acute lymphoblastic leukaemia but not B cell disease: a report from the Children's Oncology Group

Kinjo T, Ham-Terhune J, Peloponese JM Jr, Jeang KT

A therapeutic approach combining coenzyme Q 10 with other antioxidants might prove to be more effective to target co-existing metabolic disorders in individuals at risk for cardiovascular disease (55)

While no antagonistic interactions were observed, this screening approach identified synergistic effects between loss of ABCC1 or ABCA2 and Venetoclax treatment (Fig