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Data were normalized to vehicle-treated wells and fit with a 4-parameter logistic regression using Prism (GraphPad) with the bottom of the curve set to 1

DOI: 10.1038/s41467-025-62717-7 In contrast, different theoretical approaches for predicting aqueous solubility produced highly divergent results

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Much of Noopept cognitive effect may be mediated through its metabolite cycloprolylglycine (cPG), which concentrates preferentially in the hippocampus and has been shown to reduce hippocampal cell death, increase BDNF mRNA, and modulate inflammatory cytokine expression