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These global disparities necessitate region-specific policy planning, emphasizing both infrastructure and research capacity-building in under-resourced regions (Payami et al., 2023

Biologics [e.g., TNF- inhibitors (etanercept), IL-6R blockers (tocilizumab)]: Effective in 60 - 70% of patients but incur prohibitive costs ($20,000 - 50,000 annually), limiting accessibility (only 10 - 20% treated in low-resource settings) (5, 6)
doi: 10.3389/fimmu.2020.594071 36 ChenK.WangN.DiaoY.DongW.SunY.LiuL.et al

Ferroptosis may promote osteoclast bone resorption by inhibiting osteoblast function, thereby affecting the homeostasis and structural integrity of subchondral bone and leading to the occurrence of osteoarthritis (164, 165)

For single-nematode measurements, P sur-5::luc::gfp nematodes at the L4 stage were selected as before, washed, and transferred directly to the liquid luminescence medium
