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(2021) PDAC study confirming the TNF/NF-B axis, expanding functional pathways and converting the molecular signal into actionable drug targets with full traceability

A recent study showed that IDO2 mediates autoreactive B-cell responses in mice, contributing to an exaggerated inflammatory response and the severity of joint inflammation in a model of autoimmune arthritis [145]

Phase 2 data showed mean weight loss of up to 24.2% at 48 weeks, which, if confirmed in phase 3 trials, would surpass both CagriSema and tirzepatide

Adv Exp Med Biol 457:217-36, 1999

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