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Int J Dermatol Venereol

The increased toxicity of DCVHC relative to DCVC is presumably due to the fact that both compounds generate a toxic reactive sulfur-containing fragment following an elimination reaction

This is realized either by the direct neutralization of ROS, reduction of the peroxide levels, and reconstruction of oxidized membranes, or by iron quenching to limit ROS formation, or via lipid metabolism, as short-chain free fatty acids and cholesteryl esters neutralize ROS [5]

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