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Activation of TRPV1 restored GPX4 levels, reduced lipid peroxidation, and improved cartilage integrity in both IL-1treated chondrocytes and OA mouse models (42)

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Indirect criteria used to identify paracellular transport include the first-order kinetics in which the amount transported plotted as a function of concentration is linear, lacking the saturation typical of protein-mediated transport mechanisms [24, 30]

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Notably, reduced abundance of short-chain fatty acid (SCFA)-producing bacteria such as Faecalibacterium prausnitzii or Roseburia hominis , alongside increases in pro-inflammatory taxa, has been reported in dysbiotic gut microbiota profiles of inflammatory diseases compared with healthy controls (2729)