glutathione and multiple myeloma A recent editorial describes the science behind a study of mezigdomide, which augments the degradation of the proteins Ikaros Aiolos, to treat myeloma. Panel A shows the chemical structures Intracellular glutathione determines bortezomib cytotoxicity
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in this form it is essential for conversion of methylmalonate to succinate and synthesis of methionine from homocysteine (a reaction which also requires folate)

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This includes developing drugs that can modulate astrocyte activity or enhance their protective functions

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