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Development of appropriate therapeutic strategies to complement the assessment of sperm DNA damage is very much essential for the treatment of patients with male infertility as DNA damage in the male germ line is a major risk factor for adverse clinical outcomes including poor fertilization, impaired development of the pre-implantation embryo, miscarriage and an increased risk of morbidities and mortality in the offspring

La IA En 1998, la Junta de Alimentos y Nutricin (JNA) del Instituto de Medicina estableci una ingesta diaria recomendada (IDR) para la colina (32)

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Neuropediatrics 27:115123 Kolker S, Christensen E, Leonard JV, Greenberg CR, Boneh A, Burlina AB, Burlina AP, Dixon M, Duran M, Garcia Cazorla A, Goodman SI, Koeller DM, Kyllerman M, Muhlhausen C, Muller E, Okun JG, Wilcken B, Hoffmann GF, Burgard P (2011) Diagnosis and management of glutaric aciduria type Irevised recommendations