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There is a dearth of clinical data in humans, so any use should be cautious and supervised where legal

Drug Deliv Transl Res 12(4):758791 Gironi B, Kahveci Z, McGill B, Lechner BD, Pagliara S, Metz J, Morresi A, Palombo F, Sasse P, Petrov PG (2020) effect of DMSO on the mechanical and structural properties of model and biological membranes

High-dose supplementationparticularly intramuscular injections that can deliver 1,000 micrograms or morecreates substantially elevated serum B12 levels compared to dietary intake, which may more readily trigger these bacterial changes, though comparative studies between different forms are limited

Marcel Dekker

Frequency: one subcutaneous injection once weekly , titrating up gradually as tolerated