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Injured adult neurons regress to an embryonic transcriptional growth state

Guo, W., Li, B.-L., Zhao, J.-Y., Li, X.-M

H3K9me3 and H3K27me3 histone marks promote heterochromatin formation, reinforcing senescence-associated gene silencing.21 Senescent cells also exhibit DNA methylation changes, altering gene expression patterns.22 Senescence in Aging and Age-Related Diseases The role of cellular senescence in aging is multifaceted

Early-life and chronic exposure to di(2-ethylhexyl) phthalate enhances amyloid- toxicity associated with an autophagy-related gene in Caenorhabditis elegans Alzheimer's disease models