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Inhibiting Gln metabolism can impair SERCA activity by reducing intracellular GSH levels, which may lead to the increased expression of PD-L1

In addition, many patients are either intrinsically resistant or develop chemoresistance throughout the therapy, which can lead to tumor relapse after an initial response 7,8

The cells were then washed with PBS, and GSH and GSSG levels were determined by applying the GSH/GSSG-Glo assay according to manufacturer instructions

Nonetheless, the deletion of Nrf2 prevented the increased expression of NRF2 protein and the induction of NRF2 targets upon Gclc deletion in liver tissue (Fig

Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance