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P21 is a small tetra-peptide derived from the most active region of CNTF (ciliary neurotrophic factor), the amino acid residues 148-151

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It upregulates growth factors including VEGF and EGF

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Accordingly, daf-7 -mutant worms exhibited a slower growth rate and increased dauer entry 11

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[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential

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It is also found in plants , animal cells , and fungi

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