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Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition

The implications of NNMT inhibition extend far beyond simple cofactor availability, influencing fundamental cellular processes including mitochondrial biogenesis, oxidative stress management, and epigenetic regulation

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Nature Chemical Biology 9(5):300-306

Simultaneously, the preservation of SAM levels maintains cellular methylation capacity for essential epigenetic modifications and protein functions